5197-65-9

5197-65-9 structure

Name: Chloro-PEG5-chloride
Chemical Name: 1,2-bis[2-(2-chloroethoxy)ethoxy]ethane
CAS Number: 5197-65-9
Molecular Formula: C₁₀H₂₀Cl₂O₄
Molecular Weight: 275.16900
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-07-24 06:14:31
Modify Date: 2024-01-16 12:27:49
Chloro-PEG5-chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1,2-bis[2-(2-chloroethoxy)ethoxy]ethane
Synonyms	3,6,9,12-Tetraoxatetradecane,1,14-dichloro 2-chloro-1-(2-{2-[2-(2-chloroethoxy)ethoxy]ethoxy}ethoxy)ethane Pentaethylene glycol dichloride

Description	Chloro-PEG5-chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

4792-15-8

~89%

5197-65-9

Literature: Rey, Jimena; Garcia, Felix Clemente; Garcia, Jose Miguel Reactive and Functional Polymers, 2011 , vol. 71, # 9 p. 948 - 957

112-26-5

5197-65-9

Literature: Prelog,V.; Bedekovic,D. Helvetica Chimica Acta, 1979 , vol. 62, p. 2285 - 2303