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57602-02-5

57602-02-5 structure
57602-02-5 structure
  • Name: Bromo-PEG4-bromide
  • Chemical Name: 1,14-Dibromo-3,6,9,12-tetraoxatetradecane
  • CAS Number: 57602-02-5
  • Molecular Formula: C10H20Br2O4
  • Molecular Weight: 364.071
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-12-11 09:15:15
  • Modify Date: 2024-01-06 17:42:03
  • Bromo-PEG4-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Name 1,14-Dibromo-3,6,9,12-tetraoxatetradecane
Synonyms 3,6,9,12-Tetraoxatetradecane, 1,14-dibromo-
1,14-Dibromo-3,6,9,12-tetraoxatetradecane
1,2-bis[2-(2-bromoethoxy)ethoxy]ethane
Description Bromo-PEG4-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Mulyana Y, et al. Oligonuclear polypyridylruthenium(II) complexes incorporating flexible polar and non-polar bridges: synthesis, DNA-binding and cytotoxicity. Dalton Trans. 2011 Feb 21;40(7):1510-23.

[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Density 1.5±0.1 g/cm3
Boiling Point 373.2±32.0 °C at 760 mmHg
Molecular Formula C10H20Br2O4
Molecular Weight 364.071
Flash Point 152.9±23.6 °C
Exact Mass 361.972809
PSA 36.92000
LogP 0.80
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.489
Hazard Codes Xi
HS Code 2909199090
4792-15-8 structure

4792-15-8

~86%

57602-02-5 structure

57602-02-5

Literature: Biron, Eric; Otis, Francois; Meillon, Jean-Christophe; Robitaille, Martin; Lamothe, Julie; Van Hove, Patrick; Cormier, Marie-Eve; Voyer, Normand Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1279 - 1290
109789-39-1 structure

109789-39-1

~%

57602-02-5 structure

57602-02-5

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 3 p. 557 - 560 Steroids, , vol. 71, # 10 p. 911 - 921
55400-73-2 structure

55400-73-2

~%

57602-02-5 structure

57602-02-5

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 2 p. 636 - 643
5197-65-9 structure

5197-65-9

~%

57602-02-5 structure

57602-02-5

Literature: Canadian Journal of Chemistry, , vol. 66, p. 1097 - 1108
112-60-7 structure

112-60-7

~%

57602-02-5 structure

57602-02-5

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 2 p. 636 - 643
HS Code 2909199090
Summary 2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Chemsrc provides CAS#:57602-02-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 57602-02-5 | Chemsrc address: https://www.chemsrc.com/en/baike/670052.html

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