55400-73-2

55400-73-2 structure

Name: Ms-PEG4-Ms
Chemical Name: 1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane
CAS Number: 55400-73-2
Molecular Formula: C₁₀H₂₂O₉S₂
Molecular Weight: 350.40600
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-11-05 22:43:53
Modify Date: 2024-01-02 13:20:09
Ms-PEG4-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane
Synonyms	Oxybis(2,1-ethanediyloxy-2,1-ethanediyl) dimethanesulfonate

Description	Ms-PEG4-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

112-60-7

124-63-0

~96%

55400-73-2

Literature: Bakleh; Sol; Estieu-Gionnet; Granet; Deleris; Krausz Tetrahedron, 2009 , vol. 65, # 36 p. 7385 - 7392

112-60-7

124-63-0

~24%

55400-73-2

65883-12-7

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503

914311-67-4

124-63-0

55400-73-2

65883-12-7