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  • DC Chemicals Limited
  • China
  • Product Name: PDM2
  • Price: $450.0/100mg $750.0/250mg $1500.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

688348-25-6

688348-25-6 structure
688348-25-6 structure
  • Name: PDM 2
  • Chemical Name: 1,3-dichloro-5-[2-(4-chlorophenyl)ethenyl]benzene
  • CAS Number: 688348-25-6
  • Molecular Formula: C14H9Cl3
  • Molecular Weight: 283.580
  • Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
  • Create Date: 2016-07-10 00:28:09
  • Modify Date: 2024-01-16 10:48:06
  • PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.

Name 1,3-dichloro-5-[2-(4-chlorophenyl)ethenyl]benzene
Synonyms 1,3-Dichloro-5-[(E)-2-(4-chlorophenyl)vinyl]benzene
1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene
Benzene, 1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]-
PDM 2
Description PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.
Related Catalog
Target

Ki: 1.2±0.4 nM(AhR)[1]

In Vitro PDM2 (Compound 4b) exhibits a Ki of 1.2±0.4 nM for AhR and no affinity for estrogen receptor (ER), confirming that replacement of hydroxyl with chloride abolished binding on ER and increased dramatically the affinity for AhR[1].
References

[1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91.

Density 1.4±0.1 g/cm3
Boiling Point 394.2±42.0 °C at 760 mmHg
Molecular Formula C14H9Cl3
Molecular Weight 283.580
Flash Point 276.5±23.5 °C
Exact Mass 281.976990
LogP 6.58
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.675
Storage condition 2-8℃