63659-18-7
63659-18-7 structure
- Name: Betaxolol
- Chemical Name: betaxolol
- CAS Number: 63659-18-7
- Molecular Formula: C18H29NO3
- Molecular Weight: 307.43
- Catalog: API Circulatory system medication Antiarrhythmic drug
- Create Date: 2018-06-11 18:49:24
- Modify Date: 2024-01-03 17:02:28
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Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.Target: Beta1 Adrenergic ReceptorBetaxolol is a cardioselective beta-adrenergic receptor blocking agent. Betaxolol (5 mg/kg via i.p. injection) was administered at 24 and then 44 h following the final chronic cocaine administration. Animals treated with betaxolol during cocaine withdrawal exhibited a significant attenuation of anxiety-like behavior characterized by increased time spent in the open arms and increased entries into the open arms compared to animals treated with only saline during cocaine withdrawal. Betaxolol did not produce anxiolytic-like effects in control animals treated chronically with saline [1]. Betaxolol produces less systemic beta 2- and possibly beta 1-adrenergic receptor blockade than either timolol or levobunolol. Betaxolol may be relatively safer to use in patients with reactive airway disease than either timolol or levobunolol [2].
| Name | betaxolol |
|---|---|
| Synonyms |
(±)-1-(p-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propanol Hydrochloride
1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-[(1-methylethyl)amino]propan-2-ol hydrochloride Betaxolol MFCD00242958 (+/-)-1-{p-[2-(cyclopropylmethoxy) ethyl] phenoxy}-3-isopropylamino-2-propanol 1-{4-[2-(Cyclopropylmethoxy)ethyl]phenoxy}-3-[(1-methylethyl)amino]propan-2-olhydrochlorid Betaxololum 2-Propanol, 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-, hydrochloride (1:1) 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol 1-{4-[2-(Cyclopropylmethoxy)ethyl]phenoxy}-3-(isopropylamino)-2-propanol hydrochloride (1:1) Betaxolol [INN:BAN] 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol hydrochloride (1:1) Betaxolol hydrochloride Kerlone 1-{4-[2-(cyclopropylméthoxy)éthyl]phénoxy}-3-[(1-méthyléthyl)amino]propan-2-ol chlorhydrate Betaxolol (TN) 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol 1-{4-[2-(Cyclopropylmethoxy)-ethyl]-phenoxy}-3-isopropylamino-propan-2-ol 1-{4-[2-(Cyclopropylmethoxy)ethyl]phenoxy}-3-(isopropylamino)propan-2-ol hydrochloride (1:1) Betoptic Betaxololum [INN-Latin] Betazolol 2-propanol, 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-, hydrochloride UNII:6X97D2XT0O |
| Description | Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.Target: Beta1 Adrenergic ReceptorBetaxolol is a cardioselective beta-adrenergic receptor blocking agent. Betaxolol (5 mg/kg via i.p. injection) was administered at 24 and then 44 h following the final chronic cocaine administration. Animals treated with betaxolol during cocaine withdrawal exhibited a significant attenuation of anxiety-like behavior characterized by increased time spent in the open arms and increased entries into the open arms compared to animals treated with only saline during cocaine withdrawal. Betaxolol did not produce anxiolytic-like effects in control animals treated chronically with saline [1]. Betaxolol produces less systemic beta 2- and possibly beta 1-adrenergic receptor blockade than either timolol or levobunolol. Betaxolol may be relatively safer to use in patients with reactive airway disease than either timolol or levobunolol [2]. |
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| Related Catalog | |
| References |
[2]. Lesar, T.S., Comparison of ophthalmic beta-blocking agents. Clin Pharm, 1987. 6(6): p. 451-63. |
| Density | 1.067 g/cm3 |
|---|---|
| Boiling Point | 448ºC at 760 mmHg |
| Melting Point | 61-63°C |
| Molecular Formula | C18H29NO3 |
| Molecular Weight | 307.43 |
| Flash Point | 224.7ºC |
| PSA | 50.72000 |
| LogP | 2.78430 |
| Storage condition | -20°C Freezer |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26 |
| WGK Germany | 3 |
| RTECS | GW2967200 |
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~86%
63659-18-7 |
| Literature: Joshi, Ramesh Anna; Murugan, Muthukrishnan; Garud, Dinesh Ramesh; Borikar, Sanjay Pandurang; Gurjar, Mukund Keshav Patent: US2006/94903 A1, 2006 ; Location in patent: Page/Page column 5 ; |
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~92%
63659-18-7 |
| Literature: Di Bono; Scilimati Synthesis, 1995 , # 6 p. 699 - 702 |
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63659-18-7 |
| Literature: Journal of Medicinal Chemistry, , vol. 30, # 6 p. 1003 - 1011 |
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63659-18-7 |
| Literature: Journal of Medicinal Chemistry, , vol. 30, # 6 p. 1003 - 1011 |
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63659-18-7 |
| Literature: Journal of Medicinal Chemistry, , vol. 30, # 6 p. 1003 - 1011 |
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63659-18-7 |
| Literature: Journal of Medicinal Chemistry, , vol. 30, # 6 p. 1003 - 1011 |
| Precursor 7 | |
|---|---|
| DownStream 2 | |
