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Dayang Chem (Hangzhou) Co., Ltd.
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26844-12-2

26844-12-2 structure

26844-12-2 structure

Name: Indoramin
Chemical Name: N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide
CAS Number: 26844-12-2
Molecular Formula: C₂₂H₂₅N₃O
Molecular Weight: 347.45300
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-06-26 17:18:06
Modify Date: 2024-01-04 09:59:21
Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor[1].

Name	N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide
Synonyms	3-<2-(4-Benzamidopiperid-1-yl)ethyl>indol Indoramine [INN-French] N-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-benzamide 3-[2-(4-benzamido-1-piperidyl)ethyl]indole INDORAMIN Indoramine 3-[2-(4-benzamidopiperid-1-yl)ethyl]indole Indoramina [INN-Spanish] EINECS 248-041-5 Benzamide,N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl) Indoraminum [INN-Latin]

Description	Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
References	[1]. M Eltze, et al. In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73.

Density	1.21g/cm3
Boiling Point	600ºC at 760mmHg
Melting Point	208-210°
Molecular Formula	C₂₂H₂₅N₃O
Molecular Weight	347.45300
Flash Point	316.7ºC
Exact Mass	347.20000
PSA	48.13000
LogP	3.93360
Vapour Pressure	2.36E-14mmHg at 25°C
Index of Refraction	1.657

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV5395900

CHEMICAL NAME :: Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-

CAS REGISTRY NUMBER :: 26844-12-2

BEILSTEIN REFERENCE NO. :: 0494035

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H25-N3-O

MOLECULAR WEIGHT :: 347.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971

HS Code	2933990090

Precursor 1
26844-47-3
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%