Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Cinchonine
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Cinchonine
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Cinchonine
Price: ￥288.0/25g ￥98.0/5g ￥588.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Cinchonine ((8R,9S)-Cinchonine; LA40221)
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: Cinchonine ((8R,9S)-Cinchonine; LA40221)
Price: $50.0/100mg $100.0/250mg $200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

118-10-5

118-10-5 structure

Name: Cinchonine
Chemical Name: cinchonine
CAS Number: 118-10-5
Molecular Formula: C₁₉H₂₂N₂O
Molecular Weight: 294.39
Catalog: API Antiparasitic drug Antimalarial
Create Date: 2018-08-26 14:34:15
Modify Date: 2024-01-02 17:39:49
Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].

Name	cinchonine
Synonyms	(1S)-Quinolin-4-yl((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol homoquinidine MFCD00064372 EINECS 204-234-6 cinchonidine chinchonine Cinchonine Cinchonan-9-ol, (8α,9S)- D-CINCHONINE Cinchonin (8α,9S)-Cinchonan-9-ol

Description	Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050.

Density	1.2±0.1 g/cm3
Boiling Point	464.5±30.0 °C at 760 mmHg
Melting Point	260-263 °C
Molecular Formula	C₁₉H₂₂N₂O
Molecular Weight	294.39
Flash Point	234.7±24.6 °C
Exact Mass	294.173218
PSA	36.36000
LogP	3.35
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.652
Water Solubility	Insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD3500000

CHEMICAL NAME :: Cinchonine

CAS REGISTRY NUMBER :: 118-10-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H22-N2-O

MOLECULAR WEIGHT :: 294.43

WISWESSER LINE NOTATION :: T66 BNJ EYQ- DT66 A B CNTJ A1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 152 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - changes in motor activity (specific assay)

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 4,265,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - respiratory depression Blood - other hemolysis with or without anemia

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 205,129,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Blood - other hemolysis with or without anemia

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 205,129,1948

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H332
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R20/21/22
Safety Phrases	S26-S36-S36/37
RIDADR	1544
WGK Germany	3
RTECS	GD3500000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

560119-43-9

~53%

118-10-5

560119-45-1

Literature: Journal of Organic Chemistry, , vol. 69, # 9 p. 2983 - 2991

189309-24-8

~14%

1393446-38-2

118-10-5

Literature: Arkivoc, , vol. 2012, # 6 p. 264 - 280

189309-24-8

~30%

1393446-38-2

118-10-5

Literature: Arkivoc, , vol. 2012, # 6 p. 264 - 280

189309-24-8

118-10-5

Literature: Bulletin des Societes Chimiques Belges, , vol. 106, # 2 p. 77 - 84

118-10-5

Literature: Bulletin des Societes Chimiques Belges, , vol. 106, # 2 p. 77 - 84

118-10-5

1393446-38-2

118-10-5

Literature: Arkivoc, , vol. 2012, # 6 p. 264 - 280

71-41-0

118-10-5

485-71-2

Detail

Literature: Justus Liebigs Annalen der Chemie, , vol. 492, p. 242,255

Precursor 4
560119-43-9 189309-24-8 118-10-5 71-41-0
DownStream 10
32644-15-8 10009-70-8 536-78-7 1007128-30-4
324757-50-8 490-11-9 485-65-4 95088-20-3
118-10-5 485-71-2

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

118-10-5	485-71-2
485-70-1	5949-16-6
83348-44-1	73803-49-3
73804-28-1	312695-48-0
5949-12-2	146737-65-7
1203343-55-8	1175039-15-2
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	1375289-11-4