63585-09-1

63585-09-1 structure

Name: Foscarnet sodium
Chemical Name: trisodium phosphonoformate
CAS Number: 63585-09-1
Molecular Formula: CNa₃O₅P
Molecular Weight: 191.951
Catalog: API Synthetic anti-infective drugs Antiviral drugs
Create Date: 2018-09-25 10:31:13
Modify Date: 2024-01-02 10:36:37
Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].

Name	trisodium phosphonoformate
Synonyms	Phosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt (1:3) Trisodium dioxidophosphinecarboxylate oxide Foscanet sodium Triapten Foscarnet sodium phosphoranecarboxylic acid, dihydroxy-, oxide, trisodium salt foscarnet sodim MFCD00013973 trisodium dioxidophosphanecarboxylate oxide SODIUM FOSCARNET Phenytion Sodium Foscavir trisodium phosphonoformate FOSCARNET TRISODIUM SALT phosphonoformate sodium salt

Description	Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2].
References	[1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. [2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415. [3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24.

CHEMICAL NAME :: Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,216,1987

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4215113

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
Packaging Group	II
HS Code	2942000000

72304-84-8

~0%

63585-09-1

74270-25-0

Literature: Noren; Helgstrand; Johansson; Misiorny; Stening Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 264 - 270

91076-68-5

999-97-3

63585-09-1

Literature: Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 51/52, p. 778

HS Code	2942000000