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258276-95-8

258276-95-8 structure
258276-95-8 structure
  • Name: LEP(116-130)(mouse)
  • Chemical Name: Leptin Fragment 116-130 Amide mouse
  • CAS Number: 258276-95-8
  • Molecular Formula: C64H109N19O24S
  • Molecular Weight: 1560.73000
  • Catalog: Peptides
  • Create Date: 2018-12-26 20:39:03
  • Modify Date: 2024-01-05 16:08:14
  • LEP(116-130)(mouse) is a synthetic leptin peptide fragment.

Name Leptin Fragment 116-130 Amide mouse
Synonyms Obese Gene Peptide 116-130 Amide
LEP (116-130) (mouse)
Leptin
SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER: SCSLPQTSGLQKPES
LEPTIN (116-130) AMIDE
SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2: SCSLPQTSGLQKPES-NH2
LEP(116-130)(mouse)
Description LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
Related Catalog
In Vitro LEP-(116-130) (300 µM) is unable to inhibit AP-OB binding[1].
In Vivo LEP-(116-130) (1 mg, i.p.) results in a reduced rate of body weight gain in the presence of increased food intake compared with vehicle-injcted control mice. LEP-(116-130) significantly reduces blood glucose levels by appr 100 mg/dL. Administration of LEP-(116-130) to wild-type (+/+) C57BLKS/J-m mice for 4 or 7 days has no effect on their ability to thermoregulate[1].
Animal Admin Blood is drawn from the tail vein of each mouse 2 h before the onset of the dark period at the beginning of the study (day 0) and after 2, 4, and 6 days of treatment with 1 mg/day i.p. LEP-(116-130). Blood glucose levels are determined with a Glucometer Elite blood glucose monitor. After 4 and 7 days of treatment with 1 mg/day i.p. LEP-(116-130), sensitivity to cold is examined by placing the mice without food or water in a cold room with an ambient temperature of 4°C. Body temperature is measured with a rectal probe every hour for 4 h.
References

[1]. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9.

Molecular Formula C64H109N19O24S
Molecular Weight 1560.73000
Exact Mass 1559.76000
PSA 748.38000
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