70797-11-4
70797-11-4 structure
- Name: Cefpiramide acid
- Chemical Name: cefpiramide
- CAS Number: 70797-11-4
- Molecular Formula: C25H24N8O7S2
- Molecular Weight: 612.63700
- Catalog: API Antibiotics Cephalosporin
- Create Date: 2018-05-30 08:00:00
- Modify Date: 2024-01-02 21:22:20
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Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase[1][2].
| Name | cefpiramide |
|---|---|
| Synonyms |
CEFPIRAMIDE
Cefpiramide acid |
| Description | Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Bacterial[1][2] |
| In Vitro | Cefpiramide (0-2048 µg/mL; 16-18 hours) shows good activity to against most non-fermentative Gram-negative bacilli and Enterococci (32 µg/mL with 97% inhibition)[1]. Cefpiramide (0-2048 µg/mL; 16-18 hours) exhibits high effective to against Pseudomonas aeruginosa with MIC[50] and MIC[90] values of 4 µg/mL and 16 µg/mL separately[1]. Cell Viability Assay[1] Cell Line: 761 bacterial isolates (35 different species of common bacterial pathogens) Concentration: 0-2048 µg/mL Incubation Time: 16-18 hours Result: Showed broad-spectrum antibacterial activity. |
| In Vivo | Cefpiramide (25 mg/kg; i.v.; once) shows anti-Streptococcus pneumoniae activity in experimental pneumococcal meningitis[2]. Cefpiramide (25 mg/kg; i.v.; once) reduces bacteria in CSF more than 10[4] CFU/ml[2]. Animal Model: New Zealand white male rabbits(2-3 kg)[2]. Dosage: 25 mg/kg Administration: Intravenous injection; once. Result: Anti-Streptococcus pneumoniae. |
| References |
| Density | 1.75 g/cm3 |
|---|---|
| Melting Point | 213-215° (dec) |
| Molecular Formula | C25H24N8O7S2 |
| Molecular Weight | 612.63700 |
| Exact Mass | 612.12100 |
| PSA | 263.36000 |
| LogP | 1.04640 |
| Index of Refraction | 1.821 |
| RIDADR | NONH for all modes of transport |
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| HS Code | 3003201900 |
| HS Code | 3003201900 |
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