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87726-17-8

87726-17-8 structure
87726-17-8 structure
  • Name: Panipenem
  • Chemical Name: Panipenem
  • CAS Number: 87726-17-8
  • Molecular Formula: C15H21N3O4S
  • Molecular Weight: 339.410
  • Catalog: API Antibiotics Beta-lactamase inhibitor
  • Create Date: 2018-03-06 08:00:00
  • Modify Date: 2024-01-03 11:58:24
  • Panipenem (PAPM; CS533; RS533) is a carbapenem antibiotic with broad spectrum and potent activity against both Gram-positive and Gram-negative bacteria[1].

Name Panipenem
Synonyms (5R,6S)-3-{[(3S)-1-Ethanimidoyl-3-pyrrolidinyl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
(5R,6S)-3-{[(3S)-1-Ethanimidoylpyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-3-[[(3S)-1-(1-iminoethyl)-3-pyrrolidinyl]thio]-7-oxo-, (5R,6S)-
(5R,6S)-6-[(R)-1-Hydroxyethyl]-2-[(S)-1-acetimidoylpyrrolidin-3-ylthio]-1-carbapen-2-em-3-carboxylic Acid
PAPM
cs533
carbapenemrs-533
MFCD00865098
FAROPENEM
[5R-[3(S*),5a,6a(R*)]]-6-(1-Hydroxyethyl)-3-[[1-(1-iminoethyl)-3-pyrrolidinyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
Panipenan
(+)-(5R,6S)-3-[[(S)-1-Acetimidoyl-3-pyrrolidinyl]thio]-6-[(R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
Panipenem
Description Panipenem (PAPM; CS533; RS533) is a carbapenem antibiotic with broad spectrum and potent activity against both Gram-positive and Gram-negative bacteria[1].
Related Catalog
In Vivo Panipenem ( 50 mg/kg,i.v.) 在没有胆管插管的雄性 Wistar 大鼠中降低了血浆中 VPA 的浓度,相应的 AUC 也降低了约 20%,同时也会降低血浆中双氯芬酸的浓度[1]。
References

[1]. S Kojima, et al. Possible mechanism by which the carbapenem antibiotic panipenem decreases the concentration of valproic acid in plasma in rats. Antimicrob Agents Chemother. 1998 Dec;42(12):3136-40.  

Density 1.6±0.1 g/cm3
Boiling Point 555.5±60.0 °C at 760 mmHg
Molecular Formula C15H21N3O4S
Molecular Weight 339.410
Flash Point 289.7±32.9 °C
Exact Mass 339.125275
PSA 130.23000
LogP -3.69
Vapour Pressure 0.0±3.4 mmHg at 25°C
Index of Refraction 1.746

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CL5446511
CHEMICAL NAME :
1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-((1-(1-iminoethyl)- 3-pyrrolidinyl)thio)-7-oxo-, (5R-(3(S*),5-alpha,6-alpha(R*)))-
CAS REGISTRY NUMBER :
87726-17-8
LAST UPDATED :
199312
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H21-N3-O4-S
MOLECULAR WEIGHT :
339.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 39(Suppl 3),140,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
81 gm/kg/90D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - death
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 39(Suppl 3),144,1991