51165-07-2

51165-07-2 structure

Name: Substance P (6-11)
Chemical Name: Substance P (6-11)
CAS Number: 51165-07-2
Molecular Formula: C₃₆H₅₂N₈O₇S
Molecular Weight: 740.91200
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2018-10-11 15:11:20
Modify Date: 2024-01-06 18:45:36
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].

Name	Substance P (6-11)
Synonyms	substance P(6-11) [Gln6]substance P(6-11) glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide SUBSTANCE P FRAGMENT 6-11) L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 HEXA-SUBSTANCE P SUBSTANCE-P-(-6-11) HEXA-SUBSTANCE P H-GLN-PHE-PHE-GLY-LEU-MET-NH2 GLN-PHE-PHE-GLY-LEU-MET-NH2

Description	Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	Substance P(6-11) 在大鼠膀胱中刺激 [3H]-肌醇一磷酸 ([3H]-IP1) 的形成，EC50 值为 4 nM。
In Vivo	Substance P (6-11) (0.1-10 nM) 以剂量依赖的方式抑制大鼠胰腺分泌胰岛素和胰高血糖素。相反，在犬胰腺中，Substance P (6-11) (1-10 nM) 会增强胰岛素、胰高血糖素和生长抑素的释放[2]。
References	[1]. Y Torrens, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51. [2]. Y Chiba, et al. Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117(5):1996-2000.