89371-37-9

89371-37-9 structure

Name: Imidapril
Chemical Name: (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
CAS Number: 89371-37-9
Molecular Formula: C₂₀H₂₇N₃O₆
Molecular Weight: 405.44500
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-07-19 17:20:45
Modify Date: 2024-01-13 20:22:12
Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research[1][2].

Name	(4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
Synonyms	imidapril (4S)-3-<(2S)-2-<N-<(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl>amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylic Acid Hipertene (TN) Imidapril [BAN:INN] Imidaprilum (S)-3-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid Imidapril HCl (4S)-1-methyl-3-{(2S)-2-[N-(1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylic acid Imidapril (INN) Imidaprilum [INN-Latin] MFCD00870777

Description	Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP-9
References	[1]. Robinson DM, et al. Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. Drugs. 2007;67(9):1359-78. [2]. Yamamoto D, et al. Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9. J Mol Cell Cardiol. 2007 Dec;43(6):670-6.

Risk Phrases	R22:Harmful if swallowed. R34:Causes burns.
Safety Phrases	S26-S36/37/39
RIDADR	1759
Packaging Group	II
Hazard Class	8

89371-36-8

~94%

89371-37-9

Literature: US4508727 A1, ; US 4508727 A

117605-23-9

89371-37-9

Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1374 - 1377

Precursor 0
DownStream 2
64-17-5 89371-44-8