Name | (6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol |
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Synonyms |
Boldine chloroform
4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl- Boldin 2,6-dihydroxy-3,5-dimethoxyaporphine 5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol EINECS 207-509-9 1,10-dimethoxy-2,9-dihydroxyaporphine Uniboldina MFCD00135040 2,9-Dihydroxy-1,10-dimethoxyaporphine 1,10-Dimethoxy-6aa-aporphine-2,9-diol dl-Boldine Boldine 1,10-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol |
Description | Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1]. |
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Related Catalog | |
Target |
OPG/RANKL/RANK[1] |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 529.3±50.0 °C at 760 mmHg |
Melting Point | 162-164ºC |
Molecular Formula | C19H21NO4 |
Molecular Weight | 327.374 |
Flash Point | 273.9±30.1 °C |
Exact Mass | 327.147064 |
PSA | 62.16000 |
LogP | 2.32 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.639 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Precautionary Statements | P301 + P312 + P330 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
Hazard Codes | Xn:Harmful; |
Risk Phrases | R22 |
Safety Phrases | 1-20-24/25-45-36-26 |
RIDADR | UN 1544 |
WGK Germany | 3 |
RTECS | CE0750000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
~% 476-70-0 |
Literature: Nakasato; Nomura Chemical and Pharmaceutical Bulletin, 1959 , vol. 7, p. 780,784 Chem.Abstr., 1960 , p. 4646 |