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60084-10-8

60084-10-8 structure

Name: Tiazofurin
Chemical Name: 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
CAS Number: 60084-10-8
Molecular Formula: C₉H₁₂N₂O₅S
Molecular Weight: 260.267
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-04-14 08:00:00
Modify Date: 2024-01-08 15:56:21
Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH).

Name	2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
Synonyms	(1R)-1,4-Anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol Riboxamide D-Ribitol, 1-C-[4-(aminocarbonyl)-2-thiazolyl]-1,4-anhydro-, (1R)- 2-b-D-Ribofuranosyl-4-thiazolecarboxamide Tiazofurina [Spanish] 4-Thiazolecarboxamide, 2-β-D-ribofuranosyl- 2-β-D-Ribofuranosyl-4-thiazolecarboxamide [3H]-Tiazofurin Tiazofurine Tiazole Tiazofurin Tiazofurina Tiazofurinum 2-β-D-Ribofuranosylthiazole-4-carboxamide Tiazofurinum [Latin]

Description	Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH).
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning. 1990;8(3):161-170.

Density	1.6±0.1 g/cm3
Boiling Point	641.3±55.0 °C at 760 mmHg
Molecular Formula	C₉H₁₂N₂O₅S
Molecular Weight	260.267
Flash Point	341.6±31.5 °C
Exact Mass	260.046692
PSA	154.14000
LogP	-1.13
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.675

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ3600000

CHEMICAL NAME :: 4-Thiazolecarboxamide, 2-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 60084-10-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C9-H12-N2-O5-S

MOLECULAR WEIGHT :: 260.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 1135 mg/kg/15D-I

TOXIC EFFECTS :: Behavioral - headache Musculoskeletal - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 892 mg/kg/10D-I

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1684 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Blood - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1090 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - fluid intake

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 3425 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 20 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,5512,1985

Hazard Codes	Xi
HS Code	2934100090

Precursor 5
60084-09-5 95936-53-1 57944-10-2 23316-67-8
218145-21-2
DownStream 3
83285-83-0 92952-33-5 92952-40-4

HS Code	2934100090
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

60084-10-8	131922-31-1
131922-30-0	92952-33-5
60084-14-2	83161-83-5
83285-83-0	1159803-53-8
102977-57-1	132462-26-1
1698427-59-6	400774-87-0
93379-07-8	197654-05-0
897484-89-8	129790-86-9
128019-42-1	2138354-62-6
1702387-43-6