1289620-49-0

1289620-49-0 structure

Name: PF-04753299
Chemical Name: (2R)-4-(4-Biphenylyl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butana mide
CAS Number: 1289620-49-0
Molecular Formula: C₁₈H₂₁NO₄S
Molecular Weight: 347.42900
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-11-06 07:54:27
Modify Date: 2024-01-10 00:39:09
PF-04753299 is a potent and selective UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitor. PF-04753299 is bactericidal for the gonococcal isolates. PF-04753299 inhibits E. coli, P. aeruginosa and K. pneumoniae strains with MIC90 values of 2 μg/ml, 4 μg/ml and 16 μg/ml, respectively. PF-04753299 is used for the study of gram-negative bacteria infection[1].

Name	(2R)-4-(4-Biphenylyl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butana mide

Description	PF-04753299 is a potent and selective UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitor. PF-04753299 is bactericidal for the gonococcal isolates. PF-04753299 inhibits E. coli, P. aeruginosa and K. pneumoniae strains with MIC90 values of 2 μg/ml, 4 μg/ml and 16 μg/ml, respectively. PF-04753299 is used for the study of gram-negative bacteria infection[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: bacterial[1]
References	[1]. Constance M John, et al. Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors. J Antimicrob Chemother. 2018 Aug 1;73(8):2064-2071.

RIDADR	NONH for all modes of transport