40105-60-0

40105-60-0 structure

Name: kievitone
Chemical Name: kievitone
CAS Number: 40105-60-0
Molecular Formula: C₂₀H₂₀O₆
Molecular Weight: 356.36900
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2016-07-10 12:20:39
Modify Date: 2024-01-06 21:18:54
Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity[1][2].

Name	kievitone
Synonyms	3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one 3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen-4-one Kievitone

Description	Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Kievitone (0-40 μM; 4 天) 抑制雌激素受体 (ER) 阳性乳腺癌细胞株 MCF-7 和 T47D 以及 ER 阴性乳腺癌细胞株 SKBR3 的增殖 (IC50 值为 5-18 μM)[2]。 Kievitone (0-40 μM; 48 h) 抑制由胰岛素样生长因子 1、胰岛素样生长因子 2、碱性成纤维细胞生长因子或转化生长因子 α 刺激的 MCF-7 细胞的 DNA 合成[2]。 Cell Viability Assay[2] Cell Line: MCF-7, T47D and SKBR3 cells Concentration: 0-40 μM Incubation Time: 4 days Result: Inhibited breast cancer cell proliferation in a dose-dependent manner.
References	[1]. Smith DA, et, al. Kievitone: the principal antifungal component of “substance II” isolated from Rhizoctonia-infected bean tissues. 1973 Apr;3(14):179-84. [2]. Hoffman R. Potent inhibition of breast cancer cell lines by the isoflavonoid kievitone: comparison with genistein. Biochem Biophys Res Commun. 1995 Jun 15;211(2):600-6.