633-35-2

633-35-2 structure

Name: 1,4,6-androstatrien-3,17-dione
Chemical Name: androsta-1,4,6-triene-3,17-dione
CAS Number: 633-35-2
Molecular Formula: C₁₉H₂₂O₂
Molecular Weight: 282.377
Catalog: Research Areas Endocrinology
Create Date: 2018-12-26 06:23:04
Modify Date: 2024-01-02 12:09:01
Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2].

Name	androsta-1,4,6-triene-3,17-dione
Synonyms	Conchinin 1,4,6-androstatrien-3,17-dione QUINDINE Androsta-1,4,6-triene-3,17-dione Chinidin androst-1,4,6-triene-3,17-dione Kinidin Cin-quin Coccinine Quinidex QUNIDINE PITAYINE Pitayin 1,4,6-Androstatriene-3,17-dione Androsta-1,4,6-trien-3,17-dion

Description	Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2].
Related Catalog	Research Areas >> Endocrinology Research Areas >> Neurological Disease Signaling Pathways >> Others >> Aromatase
Target	Ki: 0.18 μM (aromatase)[1]
In Vivo	Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations[2]. Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis [1]. Animal Model: Rats (220-250 g)[2] Dosage: 25 mg/kg, 100 mg/kg Administration: Subcutaneous injection Result: Prevented the normal rise in ovarian estradiol concentrations with a single injection 3 hours before the time of the estrogen surge on proestrus.
References	[1]. Covey DF, et al. Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity. Endocrinology. 1981 Apr;108(4):1597-9. [2]. Brodie AM, et al. Antifertility effects of an aromatase inhibitor, 1,4,6-androstatriene-3, 17-dione. Endocrinology. 1979 Jan;104(1):118-21.

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - behavioral

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 51,1273,1994

Safety Phrases	22-24/25