Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Fangchinoline
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Fangchinoline
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Fangchinoline
Price: ￥988.0/200mg ￥168.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Fangchinoline
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Fangchinoline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

436-77-1

436-77-1 structure

Name: Fangchinoline
Chemical Name: Fangchinoline
CAS Number: 436-77-1
Molecular Formula: C₃₇H₄₀N₂O₆
Molecular Weight: 608.723
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-03-24 08:00:00
Modify Date: 2024-01-01 19:29:46
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing[1]. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK[2]. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer[3].

Name	Fangchinoline
Synonyms	Berbaman-7-ol, 6,6',12-trimethoxy-2,2'-dimethyl- Fangquinoline FF-0018 d,l-Fangchinolin (S,S)-(+)-tetrandine 12-O-MethylatherosperMoline (1β)-6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol Tetrandrine B 6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol Hanfangichin B N1799 I06-1344 THALRUGOSINE Fangchinoline 7-o-demethyltetrandrine

Description	Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing[1]. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK[2]. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer[3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK Signaling Pathways >> Autophagy >> Autophagy
Target	HIV-1 replication[1]; Focal adhesion kinase (FAK)[2]; apoptosis; autophagy[3]
In Vitro	Fangchinoline (2.5-40 µM; 24-96 hours) inhibits both T24 and 5637 cells in dose-dependent manner, the IC50 values of Fangchinoline in T24 cells are 19.0 µM (24 h), 12.0 µM (48 h) and 7.57 µM (72 h), and 11.9 µM (24 h), 9.92 µM (48 h) and 7.13 µM (72 h) in 5637 cells[1]. Fangchinoline (5 µM; 24 hours) induces a significant increase in the LC3-II/LC3-I ratio and a decrease in p62 in both T24 and 5637 cells, and causes a significant increase in the cleavage of caspase-3[1]. Cell Viability Assay[3] Cell Line: T24 and 5637 cells Concentration: 2.5 µM; 5 µM; 10 µM; 20 µM; 30 µM; 40 µM Incubation Time: 24 hours; 48 hours; 96 hours Result: Inhibited both T24 and 5637 cells proliferation. Western Blot Analysis[3] Cell Line: T24 and 5637 cells Concentration: 5 µM Incubation Time: 24 hours Result: Incresed LC3-II/LC3-I ratio and the cleavage of caspase-3.
References	[1]. Wan Z, et al. Fangchinoline inhibits human immunodeficiency virus type 1 replication by interfering with gp160 proteolytic processing. PLoS One. 2012;7(6):e39225. [2]. Guo B, et al. Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. J Drug Target. 2015 Apr;23(3):266-74. [3]. Fan B, et al. Fangchinoline Induces Apoptosis, Autophagy and Energetic Impairment in Bladder Cancer. Cell Physiol Biochem. 2017;43(3):1003-1011.

Density	1.2±0.1 g/cm3
Boiling Point	709.7±60.0 °C at 760 mmHg
Molecular Formula	C₃₇H₄₀N₂O₆
Molecular Weight	608.723
Flash Point	383.0±32.9 °C
Exact Mass	608.288635
PSA	72.86000
LogP	3.78
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.602
Storage condition	2-8C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9280000

CHEMICAL NAME :: Berbaman-7-ol, 2,2'-dimethyl-6,6',12-trimethoxy-, (1-beta)-

CAS REGISTRY NUMBER :: 436-77-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C37-H40-N2-O6

MOLECULAR WEIGHT :: 608.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976

518-34-3

~36%

83113-25-1

21008-67-3

83087-72-3

Detail

Literature: Pachaly; Praest Archiv der Pharmazie, 1982 , vol. 315, # 7 p. 589 - 597

518-34-3

~36%

21008-67-3

26137-45-1

83087-72-3

Detail

Literature: Pachaly; Praest Archiv der Pharmazie, 1982 , vol. 315, # 7 p. 589 - 597

518-34-3

~32%

436-77-1

Literature: Kunitomo, Jun-ichi; Oshikata, Megumi; Akasu, Michinori; Ishii, Hisashi Heterocycles, 1992 , vol. 34, # 5 p. 937 - 942

518-34-3

~35%

83113-25-1

21008-67-3

26137-45-1

Detail

Literature: Pachaly; Praest Archiv der Pharmazie, 1982 , vol. 315, # 7 p. 589 - 597

Precursor 1
518-34-3
DownStream 2
477-57-6 83087-75-6

436-77-1	33889-68-8
118160-59-1	83087-75-6
125247-70-3	1158522-08-7
940364-43-2	134104-43-1
131615-57-1	6906-52-1
941009-03-6	930439-75-1
473544-78-4	1018584-77-4
1375289-11-4