777075-44-2
777075-44-2 structure
- Name: cis-ACCP
- Chemical Name: cis-ACCP
- CAS Number: 777075-44-2
- Molecular Formula: C7H15N2O4P
- Molecular Weight: 222.179
- Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
- Create Date: 2017-05-25 01:13:58
- Modify Date: 2024-02-05 17:53:33
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cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases[1].
| Name | cis-ACCP |
|---|---|
| Synonyms | Phosphonic acid, [[[(1R,2S)-2-aminocyclohexyl]amino]carbonyl]- |
| Description | cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases[1]. |
|---|---|
| Related Catalog | |
| Target |
MMP-2:4 μM (IC50) MMP-9:20 μM (IC50) |
| In Vitro | cis-ACCP 可以抑制 MMP-2 和 MMP-9，IC50 值分别为 4 μM 和 20 μM[1]。 |
| In Vivo | cis-ACCP（i.p.；50、250、500 mg/kg；每天一次，持续两周）没有显示出毒性作用并减少小鼠转移形成[1]。 cis-ACCP（口服，i.v.，i.p.；50、150 mg/kg）仅分布在细胞外液中[1]。 Animal Model: C57BL mice[1] Dosage: 50, 250, 500 mg/kg; 12.5 to 50 mg/kg Administration: Oral, intraperitoneal, daily for two weeks; daily, 21 days Result: Showed no toxic effects and showed 50-85% inhibition of metastasis formation, depending on the dose. Animal Model: Rats[1] Dosage: 50, 150 mg/kg Administration: Oral, intravenous, intraperitoneal Result: Showed 84% of the intravenously administered drug are excreted unchanged. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C7H15N2O4P |
| Molecular Weight | 222.179 |
| Exact Mass | 222.076950 |
| PSA | 122.46000 |
| LogP | -2.04 |
| Index of Refraction | 1.544 |