449173-19-7

449173-19-7 structure

Name: VPC 23019
Chemical Name: N-(3-Octylphenyl)-O-phosphono-D-serinamide
CAS Number: 449173-19-7
Molecular Formula: C₁₇H₂₉N₂O₅P
Molecular Weight: 372.39600
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2016-05-23 04:47:18
Modify Date: 2024-01-04 10:21:48
VPC23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and a agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively)[1].

Name	N-(3-Octylphenyl)-O-phosphono-D-serinamide

Description	VPC23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and a agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively)[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Inflammation/Immunology
Target	pKi: 7.86 (S1P1); 5.93 (S1P3). pEC50: 6.58 (S1P1); 7.07 (S1P3)[1]
References	[1]. Davis MD, et al. Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem. 2005 Mar 18;280(11):9833-41. Epub 2004 Dec 8.