VPC 23019

Modify Date: 2024-01-04 10:21:48

VPC 23019 Structure
VPC 23019 structure
Common Name VPC 23019
CAS Number 449173-19-7 Molecular Weight 372.39600
Density N/A Boiling Point N/A
Molecular Formula C17H29N2O5P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VPC 23019


VPC23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and a agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively)[1].

 Names

Name N-(3-Octylphenyl)-O-phosphono-D-serinamide

 VPC 23019 Biological Activity

Description VPC23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and a agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively)[1].
Related Catalog
Target

pKi: 7.86 (S1P1); 5.93 (S1P3). pEC50: 6.58 (S1P1); 7.07 (S1P3)[1]

References

[1]. Davis MD, et al. Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem. 2005 Mar 18;280(11):9833-41. Epub 2004 Dec 8.

 Chemical & Physical Properties

Molecular Formula C17H29N2O5P
Molecular Weight 372.39600
Exact Mass 372.18100
PSA 135.18000
LogP 4.31450
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