VPC-18005
Modify Date: 2024-01-04 17:52:10
VPC-18005 structure
|
Common Name | VPC-18005 | ||
|---|---|---|---|---|
| CAS Number | 2242480-48-2 | Molecular Weight | 319.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H17N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VPC-18005VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity[1]. |
| Name | VPC-18005 |
|---|
| Description | VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity[1]. |
|---|---|
| Related Catalog | |
| In Vitro | VPC-18005 is found to inhibit pETS-luc reporter activity in PNT1B-ERG and VCaP cells with IC50 values of 3 and 6 μM, respectively[1]. VPC-18005 could suppress ERG reporter activity without exhibiting overt cytotoxicity[1]. VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro[1]. VPC-18005 can antagonize the metastatic potential of ERG-expressing prostate cells[1]. The exposure of larvae to 1 or 10 µM of VPC-18005 produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh[2]. Cell Viability Assay[1] Cell Line: PNT1B-Mock cells and PNT1B-ERG cells. Concentration: 5 µM. Incubation Time: 24 h. Result: Inhibited migration and invasion of prostate cell lines in vitro. |
| References |
| Molecular Formula | C15H17N3O3S |
|---|---|
| Molecular Weight | 319.38 |