136904-69-3

136904-69-3 structure

Name: 2'-THIOADENOSINE
Chemical Name: (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-sulfanyloxolan-3-ol
CAS Number: 136904-69-3
Molecular Formula: C₁₀H₁₃N₅O₃S
Molecular Weight: 283.31
Create Date: 2017-09-13 14:36:37
Modify Date: 2024-01-14 09:04:40
2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site[1].

Name	(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-sulfanyloxolan-3-ol
Synonyms	2'-Thioadenosine

Description	2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	ErbB1 ErbB2:45 μM (IC50)
In Vitro	2'-Thioadenosine (50 µM) 对 FGF，PDGF 和胰岛素受体酪氨酸激酶没有活性[1]。 2'-Thioadenosine 使 ErbB-1 共价失活，这种失活可被 1 mM Dithiothreitol 逆转[1]。
References	[1]. Singh J, et, al. Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases. J Med Chem. 1997 Mar 28;40(7):1130-5.