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518-18-3

518-18-3 structure
518-18-3 structure
  • Name: (+/-)-Evodiamine
  • Chemical Name: 1-Amino-2-bromo-4-{[3-(dimethylamino)propyl]amino}-9,10-anthraqui none
  • CAS Number: 518-18-3
  • Molecular Formula: C19H17N3O
  • Molecular Weight: 303.358
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2018-05-03 08:00:00
  • Modify Date: 2024-01-03 14:33:07
  • (±)-Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±)-Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their apoptosis[1].

Name 1-Amino-2-bromo-4-{[3-(dimethylamino)propyl]amino}-9,10-anthraqui none
Synonyms EVODIAMINE PLANT EXTRACT
8,13,13b,14-Tetrahydro-14-methylindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Indolo(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-
Indol(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (13bS)-
d-Evodiamine
Evodiamine
Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (13bS)-
)-Evodiamine
Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-
14-Methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Evodia rutaecarpa E.P.
Indol(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (S)-
(13bS)-14-Methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Description (±)-Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±)-Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their apoptosis[1].
Related Catalog
Target

Top1

References

[1]. Dong G, et, al. New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations. J Med Chem. 2012 Sep 13;55(17):7593-613.

Density 1.4±0.1 g/cm3
Boiling Point 575.1±50.0 °C at 760 mmHg
Melting Point 272 °C
Molecular Formula C19H17N3O
Molecular Weight 303.358
Flash Point 301.6±30.1 °C
Exact Mass 303.137177
PSA 75.43000
LogP 1.64
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.764
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%