175735-93-0

175735-93-0 structure

Name: α-Conotoxin MII TFA
Chemical Name: α-conotoxin MII
CAS Number: 175735-93-0
Molecular Formula: C₆₇H₁₀₃N₂₃O₂₂S₄
Molecular Weight: 1710.94000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2016-11-08 13:26:39
Modify Date: 2024-01-22 18:13:23
α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors [1][2][3].

Name	α-conotoxin MII
Synonyms	VU 0155041 Alpha-Conotoxin MII

Description	α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors [1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	IC50: 0.5 nM (α3β2)[1].
In Vitro	α-Conotoxin MII (0.5-3.5 nM) blocks ACh responses in oocytes expressing α3β2 nicotinic acetylcholine receptors[1][2].
References	[1]. G E Cartier, et al. A New Alpha-Conotoxin Which Targets alpha3beta2 Nicotinic Acetylcholine Receptors. J Biol Chem. 1996 Mar 29;271(13):7522-8. [2]. S C Harvey, et al. Determinants of Specificity for Alpha-Conotoxin MII on alpha3beta2 Neuronal Nicotinic Receptors. Mol Pharmacol. 1997 Feb;51(2):336-42. [3]. J M McIntosh, et al. Conus Peptides: Novel Probes for Nicotinic Acetylcholine Receptor Structure and Function. Eur J Pharmacol. 2000 Mar 30;393(1-3):205-8.