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134-03-2

134-03-2 structure
134-03-2 structure
  • Name: sodium ascorbate
  • Chemical Name: Sodium L-Ascorbate
  • CAS Number: 134-03-2
  • Molecular Formula: C6H7NaO6
  • Molecular Weight: 198.106
  • Catalog: API Vitamins and minerals Vitamin C drugs
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2024-01-02 12:09:50
  • L-Ascorbic acid (sodium) is a more bioavailable form of vitamin C that is an antioxidant agent.
Name Sodium L-Ascorbate
Synonyms EINECS 205-126-1
Sodium ascorbate
L-Ascorbic Acid Sodium Salt
Vitamine C sodium salt,Vitamin C sodium salt
(+)-Sodium L-ascorbate (L(+)-Ascorbic acid sodium salt
SodiuM L-Ascorbate
L(+)-Ascorbic acid sodium salt,Vitamin C sodium salt
MFCD00082340
Vitamin C Sodium Salt
L(+)-Ascorbic acid sodium salt,E301
Description L-Ascorbic acid (sodium) is a more bioavailable form of vitamin C that is an antioxidant agent.
Related Catalog
In Vitro Vitamin C (L-ascorbic acid), a known enhancer of collagen deposition, has also been identified as an inhibitor of elastogenesis[1]. The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by sodium L-ascorbate (10 mM), and the effective ingredients in the medium show a relative molecular mass below 5,000[2].
In Vivo Tg rats treated with sodium L-ascorbate show a higher incidence of carcinoma (29.6%), compared to those without sodium L-ascorbate (15.4%). Independent of the sodium L-ascorbate treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[3]. After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the sodium L-ascorbate-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the sodium L-ascorbate-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[4].
Animal Admin A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven (group 1) and 13 (group 2) rats are given a powdered MF diet with or without 5% sodium L-ascorbate, respectively. Similarly, a total of 42 7-week-old male Non-tg rats are divided into 2 groups, and 30 (group 3) and 12 (group 4) animals are given a diet with or without 5% sodium L-ascorbate, respectively.
References

[1]. Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.

[2]. Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50.

[3]. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.

[4]. Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.
Density 1.799 g/cm3
Boiling Point 552.7ºC at 760 mmHg
Melting Point 220 °C (dec.)(lit.)
Molecular Formula C6H7NaO6
Molecular Weight 198.106
Flash Point 238.2ºC
Exact Mass 198.014038
PSA 110.05000
Vapour Pressure 1.62E-14mmHg at 25°C
Index of Refraction 105.5 ° (C=10, H2O)
Water Solubility 620 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CI7671000
CHEMICAL NAME :
L-Ascorbic acid, monosodium salt
CAS REGISTRY NUMBER :
134-03-2
LAST UPDATED :
199709
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C6-H7-O6.Na
MOLECULAR WEIGHT :
198.12
WISWESSER LINE NOTATION :
T5OV EHJ CQ DQ EYQ1Q &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
500 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 8,299,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0461 No. of Facilities: 474 (estimated) No. of Industries: 5 No. of Occupations: 16 No. of Employees: 16211 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0461 No. of Facilities: 705 (estimated) No. of Industries: 11 No. of Occupations: 28 No. of Employees: 24087 (estimated) No. of Female Employees: 15231 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases R68
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS CI7671000
Precursor  0

DownStream  2


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