Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzoic acid,5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

125697-92-9

125697-92-9 structure

Name: lavendustin A
Chemical Name: lavendustin a
CAS Number: 125697-92-9
Molecular Formula: C₂₁H₁₉NO₆
Molecular Weight: 381.37900
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-03-03 08:00:00
Modify Date: 2024-01-07 09:56:22
Lavendustin A (RG-14355), isolated from Streptomyces Griseolavendus, is a potent, specific and ATP-competitive inhibitor of tyrosine kinase, with an IC50 of 11 ng/mL for EGFR-associated tyrosine kinase[1]. It suppresses VEGF-induced angiogenesis and blocks the induction of LTPGABA-A[2][3].

Name	lavendustin a
Synonyms	MFCD00153822 Lavendustin A 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid

Description	Lavendustin A (RG-14355), isolated from Streptomyces Griseolavendus, is a potent, specific and ATP-competitive inhibitor of tyrosine kinase, with an IC50 of 11 ng/mL for EGFR-associated tyrosine kinase[1]. It suppresses VEGF-induced angiogenesis and blocks the induction of LTPGABA-A[2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	IC50: 11 ng/mL (EGFR-associated tyrosine kinase)[1].
References	[1]. Onoda T, et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989 Nov-Dec;52(6):1252-7. [2]. Hu DE, et al. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114(2):262-8. [3]. Gubellini P, et al. Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rat hippocampus. J Neurosci. 2005 Jun 15;25(24):5796-802.

Boiling Point	741.7ºC at 760 mmHg
Melting Point	205-215 °C
Molecular Formula	C₂₁H₁₉NO₆
Molecular Weight	381.37900
Flash Point	402.4ºC
Exact Mass	381.12100
PSA	121.46000
LogP	3.41400
Appearance	crystalline
Vapour Pressure	4.23E-23mmHg at 25°C
Storage condition	−20°C
Stability	Moisture Sensitive: Hygroscopic
Water Solubility	DMSO: soluble