Name | 5-[(3S)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran-2-yl]-1,3-benzodioxole |
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Synonyms |
5-{(2R,3R)-7-methoxy-3-methyl-5-[(1E)-prop-1-en-1-yl]-2,3-dihydro-1-benzofuran-2-yl}-1,3-benzodioxole
Eupomatenoid-8 1,3-Benzodioxole, 5-[(2R,3R)-2,3-dihydro-7-methoxy-3-methyl-5-[(1E)-1-propen-1-yl]-2-benzofuranyl]- (-)-Licarin B 5-{(2R,3R)-7-Methoxy-3-methyl-5-[(1E)-1-propen-1-yl]-2,3-dihydro-1-benzofuran-2-yl}-1,3-benzodioxole |
Description | Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway[1][2][3]. |
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Related Catalog | |
In Vitro | Licarin B (5 μM, 10 μM, 15 μM. 8 days) moderately increases TG accumulation during adipogenic differentiation and showed partial PPARg agonist activity in 3T3-L1 preadipocytes[2]. Cell Viability Assay[1] Cell Line: 3T3-L1 cell. Concentration: 1-500 μM. Incubation Time: 48 h. Result: Did not cause significant cell death up to 500 μM concentration. Cell Viability Assay[1] Cell Line: 3T3-L1 cell. Concentration: 5 μM, 10 μM, 15 μM. Incubation Time: 8 days (replaced every 2 days). Result: LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 428.5±45.0 °C at 760 mmHg |
Molecular Formula | C20H20O4 |
Molecular Weight | 324.370 |
Flash Point | 131.4±35.6 °C |
Exact Mass | 324.136169 |
PSA | 36.92000 |
LogP | 5.08 |
Vapour Pressure | 0.0±1.0 mmHg at 25°C |
Index of Refraction | 1.608 |
Storage condition | 2-8C |