Name | methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate,hydrobromide |
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Synonyms |
1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure-methylester,Hydrobromid
MFCD00039041 Methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide (1:1) EINECS 206-087-3 Arecaidine methyl ester hydrobromide methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (1:1) Arecoline Methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide ARECOLINE HBr Methyl 1,2,5,6-Tetrahydro-1-methylnicotinate Hydrobromide Methyl-1-methyl-1,2,5,6-tetrahydro-3-pyridincarboxylathydrobromid 1-methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester,hydrobromide arecolinium bromide Methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide (1:1) Arecoline hydrobromide Taeniolin Arecoline bromide 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic Acid Methyl Ester Hydrobromide 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (9CI) 1-Méthyl-1,2,5,6-tétrahydro-3-pyridinecarboxylate de méthyle bromhydrate Arecoline (hydrobromide) |
Description | Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist. Target: mAChRArecoline is an alkaloid found in the areca nut. Arecoline. a drug obtained from the Areca Catechu L., induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.) which was prevented by the muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.) and S-(-)-ET-126 (0.01 microg per mouse i.c.v.) [1]. Arecoline exerts its excitatory actions by binding to M2-muscarinic receptors on the cell membrane of neurons of the locus coeruleus [2]. Arecoline (1 nM - 1 microM) produced a concentration-dependent contraction in both the longitudinal and the circular smooth muscle of rabbit colon. Atropine (10 microM) abolished the arecoline (80 nM)--induced contraction. M3 receptor antagonist, 4 - DAMP (0.4 microM), abolished the arecoline (80 nM)--related response, whereas M2 receptor antagonist, gallamine (0.4 microM), did not affect the effect of arecoline. These results suggest that arecoline excites the colonic motility via M3 receptor in rabbits [3]. |
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Related Catalog | |
References |
Boiling Point | 209ºC at 760mmHg |
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Melting Point | 171-175 °C |
Molecular Formula | C8H14BrNO2 |
Molecular Weight | 236.106 |
Flash Point | 81.1ºC |
Exact Mass | 235.020782 |
PSA | 29.54000 |
LogP | 1.31730 |
Storage condition | Refrigerator |
Water Solubility | H2O: 0.1 g/mL, clear, colorless |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Precautionary Statements | P301 + P312 + P330 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn:Harmful; |
Risk Phrases | R22 |
Safety Phrases | S45-S38-S36/37/39-S28A |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | QT2275000 |
HS Code | 29399990 |
Precursor 0 | |
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DownStream 10 | |
HS Code | 2933399090 |
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Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |