498-96-4

498-96-4 structure

Name: Guvacine
Chemical Name: guvacine
CAS Number: 498-96-4
Molecular Formula: C₆H₁₀ClNO₂
Molecular Weight: 127.141
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-12-19 22:03:46
Modify Date: 2024-01-10 10:57:18
Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].

Name	guvacine
Synonyms	1,2,5,6-Tetrahydro-pyridin-3-carbonsaeure 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid 1,2,5,6-tetrahydropyridine-3-carboxylic acid 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE 3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro GUVACINE HYDROCHLORIDE GUVACINE-HCL 1,2,3,6-tetrahydropyridine-5-carboxylic acid 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro- 1,2,5,6-Tetrahydronicotinic acid Guvacine hydrochloride,1,2,5,6-Tetrahydropyridine-3-carboxylicacidhydrochloride Guvacine UNII:41538P325K MFCD00055191 1,2,5,6-tetrahydro-pyridine-3-carboxylic acid

Description	Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	IC50: 39 μM (rat GAT-1), 58 μM (rat GAT-2), 378 μM (rat GAT-3), 14 μM (human GAT-1), 119 μM (huam GAT-3) and 1870 μM (human BGT-3)[1]
References	[1]. L A Borden, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.