Name | 2-amino-3-phosphonopropanoic acid |
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Synonyms |
Alanine, 3-phosphono-
DL-2-Amino-3-phosphonopropionic acid 2-Amino-3-phosphonopropionic acid D,L-2-Amino-3-phosphonopropionic Acid (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST 2-amino-3-phosphopropanoic acid 3-Phosphonoalanine UNII:0H89G8110O 3-Phosphono-DL-alanine Aminophosphonopropionic acid DL-2-Amino-4-phosphonopropionic acid (±)-2-Amino-3-phosphonopropionic acid 2-amino-3-phosphonopropionate 2-amino-3-phosphonopropanoic acid 2-AP3 |
Description | DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect[1][2][3]. |
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Related Catalog | |
Target |
mGluR 1 mGluR 5 |
In Vitro | DL-AP3 (10 µM,6 小时) 减轻原代神经元中氧-葡萄糖剥夺 (OGD) 引起的损伤 (细胞活力)[1]。 DL-AP3 (10 µM,6 小时) 恢复原代神经元中 OGD 诱导的 p-Akt1 水平降低和细胞色素 C 增加[1]。 DL-AP3 (1-100 µM) 抑制大鼠脑磷酸丝氨酸磷酸酶的活性[2]。 DL-AP3 (10μM, 10min) 联合 SKF81297 (5μM) 在 Fmr1 KO 小鼠的切片中诱导显著的的长时程增强 (LTP)[3]。 Western Blot Analysis[1] Cell Line: Primary neurons Concentration: 10 µM Incubation Time: 6 h Result: Increased the decreased levels of p-Akt1, and decreased the increase of cytochrome C. |
In Vivo | DL-AP3 (4 mg/kg, i.p., 持续 5 周) 联合 SKF81297 (1 mg/kg, i.p.) 减少 Fmr1 KO 小鼠多动表型[3]。 DL-AP3 (i.c.v.) 阻断绵羊内脏痛症状的发展,以及血浆中神经内分泌学变化[4]。 Animal Model: Fmr1 KO mice[3] Dosage: 4 mg/kg with SKF81297 (1 mg/kg) Administration: i.p., for 5 weeks. Result: Reduced the distance traveled by Fmr1 KO mice (open-field test). Reduced the swim latency on the final day in the Fmr1 KO mice (Morris Water Maze test). |
References |
Density | 1.8±0.1 g/cm3 |
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Boiling Point | 481.6±55.0 °C at 760 mmHg |
Molecular Formula | C3H8NO5P |
Molecular Weight | 169.073 |
Flash Point | 245.1±31.5 °C |
Exact Mass | 169.014008 |
PSA | 130.66000 |
LogP | -2.29 |
Vapour Pressure | 0.0±2.6 mmHg at 25°C |
Index of Refraction | 1.559 |
Precursor 0 | |
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DownStream 1 | |