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Product Name: Senecionine N-oxide
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Product Name: [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione,3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-,12-oxide, (3Z,5R,6R,14aR,14bR)-
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13268-67-2

13268-67-2 structure

13268-67-2 structure

Name: Senecionine N-oxide
Chemical Name: Senecionine, N-oxide
CAS Number: 13268-67-2
Molecular Formula: C₁₈H₂₅NO₆
Molecular Weight: 351.39400
Catalog: Research Areas Cancer
Create Date: 2018-04-14 08:00:00
Modify Date: 2024-01-06 15:19:20
Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2].

Name	Senecionine, N-oxide
Synonyms	12-Hydroxysenecionan-11,16-dione 4-oxide Senecionine oxide integerrimine N-oxide senecionine N-oxide

Description	Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Thomas Hartmann, et al. Senecionine n-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Phytochemistry, Volume 26, Issue 6, 1987, Pages 1639-1643 [2]. Kupchan SM, et al. Tumor inhibitors. XXII. Senecionine and senecionine N-oxide, the active principles of Senecio triangularis. J Pharm Sci. 1967 Apr;56(4):541-3.

Molecular Formula	C₁₈H₂₅NO₆
Molecular Weight	351.39400
Exact Mass	351.16800
PSA	102.26000
LogP	1.16420

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT5720000

CHEMICAL NAME :: Senecionan-11,16-dione, 12-hydroxy-, 4-oxide

CAS REGISTRY NUMBER :: 13268-67-2

LAST UPDATED :: 198912

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H25-N-O5

MOLECULAR WEIGHT :: 335.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 140 mg/kg

SEX/DURATION :: female 4-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 77,461,1988

Hazard Codes	Xi
RIDADR	UN 1544
Packaging Group	II
Hazard Class	6.1(a)

Precursor 1
130-01-8
DownStream 0