7699-35-6
7699-35-6 structure
- Name: cis-Urocanic acid
- Chemical Name: cis-urocanic acid
- CAS Number: 7699-35-6
- Molecular Formula: C6H6N2O2
- Molecular Weight: 138.12400
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2017-08-22 08:10:50
- Modify Date: 2024-01-13 12:17:14
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cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1].
| Name | cis-urocanic acid |
|---|---|
| Synonyms |
3-[1H-imidazol-4(5)-yl]
Cis-Urocanic Acid-[13C3] (E)-3-(3H-imidazol-4-yl)prop-2-enoic acid (Z)-Urocanic acid cis-Urocanic acid (Z)-2-propenoic acid (Z)-3-(1H-imidazol-4-yl)-2-propenoic acid (2Z)-3-(1H-Imidazole-4-yl)acrylic acid (Z)-3-(1H-Imidazole-4-yl)acrylic acid (Z)-3-(1H-imidazol-4-yl)prop-2-enoic acid UROCANIC ACID, CIS (Z)-3-(1H-Imidazol-4-yl)propenoic acid |
| Description | cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1]. |
|---|---|
| Related Catalog | |
| Target |
5-HT2A Receptor |
| In Vitro | Treatment with 100 μg/mL cis-Urocanic acid (cis-UCA) completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types. The 5000 μg/mL concentration is toxic[1]. Cell Viability Assay[1] Cell Line: Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs) Concentration: 10, 100, 1,000, and 5,000 μg/mL Incubation Time: 24, 48, or 72 hours Result: Treatment with 100 μg/mL completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells were observed with 100 μg/mL in both cell types. |
| References |
| Molecular Formula | C6H6N2O2 |
|---|---|
| Molecular Weight | 138.12400 |
| Exact Mass | 138.04300 |
| PSA | 65.98000 |
| LogP | 0.50750 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933290090 |
| Precursor 0 | |
|---|---|
| DownStream 1 | |
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |