Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MDL28170
Price:
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang

GL Biochem (Shanghai) Ltd.
China
Product Name: Calpain Inhibitor III
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

DC Chemicals Limited
China
Product Name: MDL-28170
Price: $550.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Taiwan Oyi peptide Co. Ltd
China
Product Name: MDL 28170
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

88191-84-8

88191-84-8 structure

88191-84-8 structure

Name: Calpain Inhibitor III
Chemical Name: Z-Val-Phe-H
CAS Number: 88191-84-8
Molecular Formula: C₂₂H₂₆N₂O₄
Molecular Weight: 382.45
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2018-08-14 15:59:12
Modify Date: 2024-01-03 10:13:33
cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration[1][2]. MDL-28170 also block γ-secretase[4].

Name	Z-Val-Phe-H
Synonyms	CARBOBEZOXY-VALINYL-PHENYLALANINALZ-VAL-PHE-CHO MFCD00798796 Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-phenylethyl]amino]carbonyl]-2-methylpropyl]-, phenylmethyl ester Carbamic acid, N-[(1S)-1-formyl-2-phenylethyl]-, phenylmethyl ester N-benzyloxycarbonyl-(S)-valinylphenylalaninal benzyl [(2S)-1-oxo-3-phenylpropan-2-yl]carbamate Benzyl [(2S)-3-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenylpropan-2-yl]amino}butan-2-yl]carbamate Z-Val-Phe-H Z-VAL-PHE-CHO (S)-(-)-2-(Benzylcarbonylamino)-3-phenylpropanal Z-L-Val-L-Phe-OH Benzyl [(2S)-1-oxo-3-phenyl-2-propanyl]carbamate CARBOBENZOXY-VALINYL-PHENYLALANINAL CALPAIN INHIBITOR III Benzyl [(2S)-3-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenyl-2-propanyl]amino}-2-butanyl]carbamate Cbz-L-Val-L-Phe-OH Z-VAL-PHE-ALDEHYDE MDL 28170 MDL-28170

Description	cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration[1][2]. MDL-28170 also block γ-secretase[4].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	Calpain[1].
In Vitro	MDL-28170 significantly and time-dependently improves the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization[1]. MDL-28170 dose-dependently inhibits brain cysteine proteinase activity (in vitro Ki= 0.01 μM)[2].
In Vivo	Treatment with MDL-28170 (50 mg/kg, i.p.) completely prevents the striatal damage in four animals in each of the two treatment groups. The numbers of necrotic neurons are reduced by 85% and 68% in animals in which MDL-28170 injections are initiated at 0.5 and 3 h of recirculation, respectively[2]. MDL-28170 (30 mg/kg, i.p.) reduces the functional and structural deterioration of corpus callosum following fluid percussion injury[3]. MDL-28170 (10 mg/kg, i.p.) significantly improves nerve function parameters in diabetic rats. MDL-28170 (3 and 10 mg/kg, i.p.) improves nociceptive behavior in diabetic rats[5].
References	[1]. Chen ZF, et al. Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL28170. Brain Res. 1997 Sep 19;769(1):188-92. [2]. Li PA, et al. Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci Lett. 1998 May 8;247(1):17-20. [3]. Ai J, et al. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J Neurotrauma. 2007 Jun;24(6):960-78. [4]. De Strooper B, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999 Apr 8;398(6727):518-22. [5]. Kharatmal SB, et al. Calpain inhibitor, MDL 28170 confer electrophysiological, nociceptive and biochemical improvement in diabetic neuropathy. Neuropharmacology. 2015 Oct;97:113-21.

Density	1.2±0.1 g/cm3
Boiling Point	450.4±45.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₆N₂O₄
Molecular Weight	382.45
Flash Point	226.2±28.7 °C
PSA	84.50000
LogP	3.77
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.571
Storage condition	2-8℃

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport