Calpain Inhibitor III

Modify Date: 2024-01-03 10:13:33

Calpain Inhibitor III structure	Common Name	Calpain Inhibitor III
	CAS Number	88191-84-8	Molecular Weight	382.45
	Density	1.2±0.1 g/cm3	Boiling Point	450.4±45.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₆N₂O₄	Melting Point	N/A
	MSDS	USA	Flash Point	226.2±28.7 °C

Use of Calpain Inhibitor III

cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration[1][2]. MDL-28170 also block γ-secretase[4].

Name	Z-Val-Phe-H
Synonym	More Synonyms

Description	cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration[1][2]. MDL-28170 also block γ-secretase[4].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	Calpain[1].
In Vitro	MDL-28170 significantly and time-dependently improves the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization[1]. MDL-28170 dose-dependently inhibits brain cysteine proteinase activity (in vitro Ki= 0.01 μM)[2].
In Vivo	Treatment with MDL-28170 (50 mg/kg, i.p.) completely prevents the striatal damage in four animals in each of the two treatment groups. The numbers of necrotic neurons are reduced by 85% and 68% in animals in which MDL-28170 injections are initiated at 0.5 and 3 h of recirculation, respectively[2]. MDL-28170 (30 mg/kg, i.p.) reduces the functional and structural deterioration of corpus callosum following fluid percussion injury[3]. MDL-28170 (10 mg/kg, i.p.) significantly improves nerve function parameters in diabetic rats. MDL-28170 (3 and 10 mg/kg, i.p.) improves nociceptive behavior in diabetic rats[5].
References	[1]. Chen ZF, et al. Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL28170. Brain Res. 1997 Sep 19;769(1):188-92. [2]. Li PA, et al. Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci Lett. 1998 May 8;247(1):17-20. [3]. Ai J, et al. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J Neurotrauma. 2007 Jun;24(6):960-78. [4]. De Strooper B, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999 Apr 8;398(6727):518-22. [5]. Kharatmal SB, et al. Calpain inhibitor, MDL 28170 confer electrophysiological, nociceptive and biochemical improvement in diabetic neuropathy. Neuropharmacology. 2015 Oct;97:113-21.

Density	1.2±0.1 g/cm3
Boiling Point	450.4±45.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₆N₂O₄
Molecular Weight	382.45
Flash Point	226.2±28.7 °C
PSA	84.50000
LogP	3.77
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.571
Storage condition	2-8℃

Calpain Inhibitor III MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport

Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons.

Int. J. Mol. Sci. 16 , 15659-69, (2015)

Excitatory/inhibitory imbalances are implicated in many neurological disorders. Previously, we showed that chronically elevated network activity induces vulnerability in neurons due to loss of signal ...

A recoverable state of axon injury persists for hours after spinal cord contusion in vivo.

Nat. Commun. 5 , 5683, (2014)

Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contus...

Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.

J. Neurosci. 35(2) , 621-33, (2015)

Deciphering and storing information coded in different firing patterns are important properties of neuronal networks, as they allow organisms to respond and adapt to external and internal events. Here...

CARBOBEZOXY-VALINYL-PHENYLALANINALZ-VAL-PHE-CHO

MFCD00798796

Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-phenylethyl]amino]carbonyl]-2-methylpropyl]-, phenylmethyl ester

Carbamic acid, N-[(1S)-1-formyl-2-phenylethyl]-, phenylmethyl ester

N-benzyloxycarbonyl-(S)-valinylphenylalaninal

benzyl [(2S)-1-oxo-3-phenylpropan-2-yl]carbamate

Benzyl [(2S)-3-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenylpropan-2-yl]amino}butan-2-yl]carbamate

Z-Val-Phe-H

Z-VAL-PHE-CHO

(S)-(-)-2-(Benzylcarbonylamino)-3-phenylpropanal

Z-L-Val-L-Phe-OH

Benzyl [(2S)-1-oxo-3-phenyl-2-propanyl]carbamate

CARBOBENZOXY-VALINYL-PHENYLALANINAL

CALPAIN INHIBITOR III

Benzyl [(2S)-3-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenyl-2-propanyl]amino}-2-butanyl]carbamate

Cbz-L-Val-L-Phe-OH

Z-VAL-PHE-ALDEHYDE

MDL 28170

MDL-28170

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MDL28170
Price: Click To Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
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GL Biochem (Shanghai) Ltd.
China
Product Name: Calpain Inhibitor III
Price: $Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

DC Chemicals Limited
China
Product Name: MDL-28170
Price: $550.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: MDL 28170
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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Price: ￥880/10 mM * 1 mL in DMSO

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Calpain Inhibitor III

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