Lck Inhibitor III

Modify Date: 2024-09-20 08:00:45

Lck Inhibitor III Structure
Lck Inhibitor III structure
Common Name Lck Inhibitor III
CAS Number 1188890-30-3 Molecular Weight 478.55
Density N/A Boiling Point N/A
Molecular Formula C25H28N6O3・H2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lck Inhibitor III


Lck Inhibitor III (compound 12h) is a potent Lck inhibitor, with an IC50 of 867 nM. Lck Inhibitor III inhibits IL-2 synthesis in Jurkat cells, with an IC50 of 1.270 μM[1].

 Names

Name Lck Inhibitor III
Synonym More Synonyms

 Lck Inhibitor III Biological Activity

Description Lck Inhibitor III (compound 12h) is a potent Lck inhibitor, with an IC50 of 867 nM. Lck Inhibitor III inhibits IL-2 synthesis in Jurkat cells, with an IC50 of 1.270 μM[1].
Related Catalog
Target

IL-2

Lck:867 nM (IC50)

References

[1]. Sabat M, et al. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorg Med Chem Lett. 2006 Dec 1;16(23):5973-7.  

 Chemical & Physical Properties

Molecular Formula C25H28N6O3・H2O
Molecular Weight 478.55
Water Solubility Soluble in DMSO (100 mg/ml), and ethanol (25 mg/ml).

 Synonyms

2-(1H-Benzo[d]imidazol-1-yl)-N-(5-methoxy-2-methylphenyl)-6-(2-morpholinoethoxy)pyrimidin-4-amine, hydrate