120443-16-5
120443-16-5 structure
- Name: Verlukast
- Chemical Name: 3-[(R)-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-[3-(dimethylamino)-3-oxopropyl]sulfanylmethyl]sulfanylpropanoic acid
- CAS Number: 120443-16-5
- Molecular Formula: C26H27ClN2O3S2
- Molecular Weight: 515.087
- Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
- Create Date: 2018-08-29 09:59:36
- Modify Date: 2024-01-11 07:00:57
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Verlukast is a potent, selective, and orally active antagonist of leukotriene receptor. Verlukast has the potential for the research of asthma[1].
| Name | 3-[(R)-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-[3-(dimethylamino)-3-oxopropyl]sulfanylmethyl]sulfanylpropanoic acid |
|---|---|
| Synonyms |
3-{[(R)-{3-[(E)-2-(7-Chloroquinolin-2-yl)vinyl]phenyl}{[3-(dimethylamino)-3-oxopropyl]sulfanyl}methyl]sulfanyl}propanoic acid
Propanoic acid, 3-[[(R)-[3-[(E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]- MK 679 3-(((aR)-m-((E)-2-(7-Chloro-2-quinolyl)vinyl)-a-((2-(dimethylcarbamoyl)ethyl)thio)benzyl)thio)propionic Acid 3-{[(R)-{3-[(E)-2-(7-Chloro-2-quinolinyl)vinyl]phenyl}{[3-(dimethylamino)-3-oxopropyl]sulfanyl}methyl]sulfanyl}propanoic acid Verlukastum (R-(E))-3-(((3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propanoic Acid 3-(((αR)-m-((E)-2-(7-Chloro-2-quinolyl)vinyl)-α-((2-(dimethylcarbamoyl)ethyl)thio)benzyl)thio)propionic acid 3-{[(R)-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}{[3-(dimethylamino)-3-oxopropyl]sulfanyl}methyl]sulfanyl}propanoic acid MK-0679 VERLUKAST |
| Description | Verlukast is a potent, selective, and orally active antagonist of leukotriene receptor. Verlukast has the potential for the research of asthma[1]. |
|---|---|
| Related Catalog | |
| Target |
leukotriene receptor[1] |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 712.3±60.0 °C at 760 mmHg |
| Molecular Formula | C26H27ClN2O3S2 |
| Molecular Weight | 515.087 |
| Flash Point | 384.6±32.9 °C |
| Exact Mass | 514.115173 |
| PSA | 121.10000 |
| LogP | 5.93 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.687 |
|
~82%
120443-16-5 |
| Literature: Hughes; Bergan; Amato; Reider; Grabowski Journal of Organic Chemistry, 1989 , vol. 54, # 8 p. 1787 - 1788 |
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120443-16-5 |
| Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 32, # 1 p. 127 - 130 |
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~51%
120443-16-5 |
| Literature: Shinkai, I; Bhupathy, M Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 1 p. 127 - 130 |
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120443-16-5 |
| Literature: Journal of Organic Chemistry, , vol. 55, # 26 p. 6252 - 6259 |
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120443-16-5 |
| Literature: Journal of Organic Chemistry, , vol. 55, # 26 p. 6252 - 6259 |
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120443-16-5 |
| Literature: Journal of Organic Chemistry, , vol. 55, # 26 p. 6252 - 6259 |
| Precursor 5 | |
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| DownStream 0 | |