Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1,3,6,7-tetrahydroxyxanthone
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: 1,3,6,7-tetrahydroxyxanthone
Price: ￥3400.0/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

DC Chemicals Limited
China
Product Name: Norathyriol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: norathyriol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

3542-72-1

3542-72-1 structure

Name: 1,3,6,7-tetrahydroxyxanthone
Chemical Name: norathyriol
CAS Number: 3542-72-1
Molecular Formula: C₁₃H₈O₆
Molecular Weight: 260.20
Catalog: Natural product Xanthone
Create Date: 2016-10-04 22:25:40
Modify Date: 2024-01-02 09:48:30
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

Name	norathyriol
Synonyms	Norathyriol magniferitin 1,3,6,7-Tetrahydroxyxanthen-9-one 1,3,6,7-Tetrahydroxyxantone 1,3,6,7-tetrahydroxyxanthone 2,4,6,7-Tetrahydroxyxanthone 1,3,6,7-Tetrahydroxy-9H-xanthen-9-one 9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-

Description	Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology
Target	PPARα:92.8 μM (IC50) PPARβ:102.4 μM (IC50) PPARγ:153.5 μM (IC50)
In Vitro	Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest[3]. Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cells[3]Cell Growth Assay WB Cell Viability Assay[3] Cell Line: Mouse skin epidermal JB6 P+ cells Concentration: 0, 1, 10, or 25 µM Incubation Time: 24 or 72 hours Result: Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death. Western Blot Analysis[3] Cell Line: JB6 P+ cells Concentration: 0, 1, 10, or 25 µM Incubation Time: 2 hours Result: Inhibited UVB-induced phosphorylation of ERKs and p90RSK.
In Vivo	Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1]. Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4]. Animal Model: Adult Kunming mice weighing 18-22 g[4] Dosage: 0.92, 1.85 and 3.7 mg/kg Administration: Administered intragastrically; twice daily for five times Result: The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.
References	[1]. Zhi-Long Shi, et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015. [2]. Ashley S Wilkinson,et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42. [3]. Jixia Li, et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70. [4]. Yanfen Niu, et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6.

Density	1.8±0.1 g/cm3
Boiling Point	595.1±50.0 °C at 760 mmHg
Molecular Formula	C₁₃H₈O₆
Molecular Weight	260.20
Flash Point	237.8±23.6 °C
Exact Mass	260.032074
PSA	111.13000
LogP	0.95
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.801

Hazard Codes	Xi
HS Code	2932999099

Precursor 9
3542-74-3 519-34-6 490-64-2 4773-96-0
42833-68-1 2054-37-7 105904-53-8 102478-32-0
59092-97-6
DownStream 5
14103-14-1 2054-37-7 519-34-6 3542-74-3
108-73-6

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3542-72-1	2054-37-7
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