1672-63-5

1672-63-5 structure

Name: 4-hydroxyantipyrine
Chemical Name: 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one
CAS Number: 1672-63-5
Molecular Formula: C₁₁H₁₂N₂O₂
Molecular Weight: 204.22500
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-04-06 08:00:00
Modify Date: 2024-01-08 22:43:14
4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2].

Name	4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one
Synonyms	MFCD00003143 1-phenyl-2,3-dimethyl-4-hydroxy-pyrazoline-5-on 4-hydroxy-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one 4-Hydroxy-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one 1-Phenyl-2,3-dimethyl-4-hydroxy-5-pyrazolone Prestwick_270 hydroxy-4 antipyrine 1,2-dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one Antipyrine,4-hydroxy 4-Hydroxyantipyrine

Description	4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	4-Hydroxyantipyrine increase the tissue-to-plasma concentration ratio of Citicoline in the brain and liver and that of thiopental sodium in the brain, liver, and heart[1]. 4-Hydroxyantipyrine enhances the blood-brain barrier (BBB) permeability of Antipyrine considering to be concerned with the increase of the Kp value of Antipyrine in the brain[2].
References	[1]. Ohkawa Y, et al. Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter. Biol Pharm Bull. 2001 May;24(5):529-34. [2]. Ohkawa Y, et al. Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter. Biol Pharm Bull. 2001 Dec;24(12):1404-10.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%