- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Ac-YVAD-CHO
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- DC Chemicals Limited
- China
- Product Name: L 709049
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: L 709049
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- Nanjing Peptide Biotech Ltd
- China
- Product Name: Acetyl-tyrosyl-valyl-alanyl-aspartal
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Vinnie
143313-51-3
143313-51-3 structure
- Name: Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)
- Chemical Name: ac-yvad-cho
- CAS Number: 143313-51-3
- Molecular Formula: C23H32N4O8
- Molecular Weight: 492.522
- Catalog: Biochemical Peptide
- Create Date: 2018-12-28 06:29:31
- Modify Date: 2024-01-04 14:58:49
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Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1].
| Name | ac-yvad-cho |
|---|---|
| Synonyms |
pase inhibitor i
acetyl-yvad-aldehyde ice inhibitor ac-yvad-aldehyde N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-alaninamide L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-((1S)-2-carboxy-1-formylethyl)- tyr-val-ala-asp-cho N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-alaninamide yvad-cho L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]- ice inhibitor i |
| Description | Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1]. |
|---|---|
| Related Catalog | |
| Target |
IL-1β:3 nM (Ki) IL-1β:0.76 nM (Ki) |
| In Vitro | Ac-YVAD-CHO inhibits IL-1β in a dose-dependent manner, with mouse and human IC50 values of 2.5 and 0.7 μM. Ac-YVAD-CHO (0.01~100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS in a dose-related manner[1]. |
| In Vivo | Ac-YVAD-CHO (10 mg/kg; i.p.; 1 hour) is absorbed from the peritoneal cavity, as well as cleared from the blood rapidly[1]. Ac-YVAD-CHO (50 mg/kg; i.p.; 1 hour) drops precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection[1]. Ac-YVAD-CHO (30 mg/kg; i.p.; 6 hours) suppresses IL-1β levels[1]. Animal Model: CD1 female mice Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: I.p.; 1 hour Result: Absorbed from the peritoneal cavity, as well as cleared from the blood rapidly. Animal Model: CD1 female mice Dosage: 50 mg/kg (Pharmacokinetic Analysis) Administration: I.p.; 1 hour Result: Dropped precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection. Animal Model: P. acnes-sensitized mice Dosage: 30 mg/kg Administration: I.p.; 6 hours Result: Suppressed IL-1β levels. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 937.7±65.0 °C at 760 mmHg |
| Molecular Formula | C23H32N4O8 |
| Molecular Weight | 492.522 |
| Flash Point | 520.9±34.3 °C |
| Exact Mass | 492.222015 |
| PSA | 191.00000 |
| LogP | 0.79 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.552 |
| Storage condition | −20°C |
| WGK Germany | 3 |
|---|