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265114-23-6

265114-23-6 structure
265114-23-6 structure
  • Name: UR-8880
  • Chemical Name: cimicoxib
  • CAS Number: 265114-23-6
  • Molecular Formula: C16H13ClFN3O3S
  • Molecular Weight: 381.81
  • Catalog: Signaling Pathways Immunology/Inflammation COX
  • Create Date: 2017-11-28 08:19:24
  • Modify Date: 2024-01-08 21:10:27
  • Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar[1].

Name cimicoxib
Synonyms 4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide
UR-8880
Cimicoxib
Description Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar[1].
Related Catalog
Target

COX-2

References

[1]. Kim TW, Lebkowska-Wieruszewska B, Owen H, Yun HI, Kowalski CJ, Giorgi M. Pharmacokinetic profiles of the novel COX-2 selective inhibitor cimicoxib in dogs. Vet J. 2014 Apr;200(1):77-81.

Density 1.49g/cm3
Boiling Point 593.1ºC at 760 mmHg
Molecular Formula C16H13ClFN3O3S
Molecular Weight 381.81
Flash Point 312.5ºC
Exact Mass 381.03500
PSA 95.59000
LogP 4.76890
Vapour Pressure 4.91E-14mmHg at 25°C
Index of Refraction 1.649