Clk1/2-in-3
Modify Date: 2024-01-10 11:10:34
Clk1/2-in-3 structure
|
Common Name | Clk1/2-in-3 | ||
|---|---|---|---|---|
| CAS Number | 1005784-60-0 | Molecular Weight | 375.42 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H21N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Clk1/2-in-3LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs[1]. |
| Name | CLK1/2-IN-3 |
|---|
| Description | LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs[1]. |
|---|---|
| Related Catalog | |
| Target |
CLK1:1.1 nM (IC50) CLK2:2.1 nM (IC50) SRPK1:130 nM (IC50) SRPK2:260 nM (IC50) SRPK3:260 nM (IC50) |
| In Vitro | CLK1/2-IN-3 (compound 3) (1.1-3.3 μM; 72 h) increases the expression of S6K mRNAs in MDA-MB-468 cells[1]. CLK1/2-IN-3 (5 μM) significantly reduces the levels of endogenous phosphorylated SR proteins[1]. CLK1/2-IN-3 (1-10 μM) shows anti-proliferative activity with GI50s of 3.4, 2.6, 2.1, 2.5, 2.2, 2.9, 1.5 μM for MDA-MB-468, A549, COLO205, HCT-116, NCI-H23, SW620, COLO320DM cells, respectively[1]. |
| References |
| Molecular Formula | C21H21N5O2 |
|---|---|
| Molecular Weight | 375.42 |