Biotin-PEG4-amide-Alkyne

Modify Date: 2024-01-08 18:44:57

Biotin-PEG4-amide-Alkyne Structure
Biotin-PEG4-amide-Alkyne structure
Common Name Biotin-PEG4-amide-Alkyne
CAS Number 1006592-45-5 Molecular Weight 528.662
Density 1.174 Boiling Point N/A
Molecular Formula C24H40N4O7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Biotin-PEG4-amide-Alkyne


Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name (3aS,4S,6aR)-Hexahydro-2-oxo-N-(15-oxo-3,6,9,12-tetraoxa-16-azanonadec-18-yn-1-yl)-1H-thieno[3,4-d]imidazole-4-pentanamide

 Biotin-PEG4-amide-Alkyne Biological Activity

Description Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.174
Molecular Formula C24H40N4O7S
Molecular Weight 528.662
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