5-Iodouridine

Modify Date: 2024-01-03 15:12:56

5-Iodouridine Structure
5-Iodouridine structure
Common Name 5-Iodouridine
CAS Number 1024-99-3 Molecular Weight 370.10
Density 2.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C9H11IN2O6 Melting Point 205-207ºC (dec.)(lit.)
MSDS Chinese USA Flash Point N/A

 Use of 5-Iodouridine


5-Iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 5-Iodouridine
Synonym More Synonyms

 5-Iodouridine Biological Activity

Description 5-Iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 2.3±0.1 g/cm3
Melting Point 205-207ºC (dec.)(lit.)
Molecular Formula C9H11IN2O6
Molecular Weight 370.10
Exact Mass 369.966156
PSA 124.78000
LogP -0.43
Index of Refraction 1.748
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 22-24/25-36/37/39-27-26
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Synthetic Route

~92%

5-Iodouridine Structure

5-Iodouridine

CAS#:1024-99-3

Literature: Kumar; Wiebe; Knaus Canadian Journal of Chemistry, 1994 , vol. 72, # 9 p. 2005 - 2010

~94%

5-Iodouridine Structure

5-Iodouridine

CAS#:1024-99-3

Literature: Asakura, Jun-ichi; Robins, Morris J. Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4928 - 4933

~%

5-Iodouridine Structure

5-Iodouridine

CAS#:1024-99-3

Literature: Journal of Organic Chemistry, , vol. 55, # 16 p. 4928 - 4933

~%

5-Iodouridine Structure

5-Iodouridine

CAS#:1024-99-3

Literature: Angewandte Chemie - International Edition, , vol. 50, # 9 p. 2155 - 2158

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles10

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Synthesis of uridine phosphoramidite analogs: reagents for site-specific incorporation of photoreactive sites into RNA sequences.

Bioconjug. Chem. 5(6) , 508-12, (1994)

The synthesis of three new photoactive RNA phosphoramidites, 5-bromouridine, 5-iodouridine, and O4-triazolouridine, is reported. The 5' OH of bromouridine and iodouridine were protected as dimethoxytr...

Phosphine containing oligonucleotides for the development of metallodeoxyribozymes.

Chem. Commun. (Camb.) (15) , 1556-8, (2007)

Novel transition metal catalysts based on oligonucleotides can be easily obtained by functionalization of 5-iodouridine with phosphine ligands, resulting in good asymmetric induction in palladium cata...

 Synonyms

5-Iodouridine
5-Iod-uridin
5-Iodoruidine
2,4-Dihydroxy-5-iodo-1-β-D-ribofuranosylpyrimidine
Uridine, 5-iodo-
5-iodo-uridine
EINECS 213-833-1
5-Jod-uridin
5-Iodo-D-uridine
MFCD00006532
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