Collagen-IN-1

Modify Date: 2024-01-02 16:49:48

Collagen-IN-1 Structure
Collagen-IN-1 structure
Common Name Collagen-IN-1
CAS Number 104260-73-3 Molecular Weight 230.26
Density N/A Boiling Point N/A
Molecular Formula C14H14O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Collagen-IN-1


Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC50 value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research[1].

 Names

Name Collagen-IN-1

 Collagen-IN-1 Biological Activity

Description Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC50 value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research[1].
Related Catalog
References

[1]. Diego Méndez, et al. Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6. Eur J Med Chem. 2020 Apr 15;192:112187.

 Chemical & Physical Properties

Molecular Formula C14H14O3
Molecular Weight 230.26