5'-DMT-5-I-2'-dU

Modify Date: 2024-01-08 15:04:57

5'-DMT-5-I-2'-dU Structure
5'-DMT-5-I-2'-dU structure
Common Name 5'-DMT-5-I-2'-dU
CAS Number 104375-88-4 Molecular Weight 656.46
Density 1.60±0.1 g/cm3(Predicted) Boiling Point N/A
Molecular Formula C30H29IN2O7 Melting Point >128 °C (decomp)
MSDS N/A Flash Point N/A

 Use of 5'-DMT-5-I-2'-dU


5’-O-DMTr-5-iodo-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione
Synonym More Synonyms

 5'-DMT-5-I-2'-dU Biological Activity

Description 5’-O-DMTr-5-iodo-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.60±0.1 g/cm3(Predicted)
Melting Point >128 °C (decomp)
Molecular Formula C30H29IN2O7
Molecular Weight 656.46
Exact Mass 656.10200
PSA 112.01000
LogP 3.81550
Storage condition 2-8℃

 Synonyms

5'-O-DMTr-IUdR
5-iodo-5'-DMT-2'-deoxyuridine
2'-Deoxy-5'-O-DMT-5-iodouridine
5'-DMT-5-I-2'-dU