RU-SKI 43
Modify Date: 2024-01-16 14:05:12
RU-SKI 43 structure
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Common Name | RU-SKI 43 | ||
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| CAS Number | 1043797-53-0 | Molecular Weight | 386.55100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H30N2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RU-SKI 43RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.IC50 value:Target: Hhat inhibitorRU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR. |
| Name | 2-((2-methylbutyl)amino)-1-(4-((m-tolyloxy)methyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethan-1-one |
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| Synonym | More Synonyms |
| Description | RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.IC50 value:Target: Hhat inhibitorRU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR. |
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| Related Catalog | |
| References |
| Molecular Formula | C22H30N2O2S |
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| Molecular Weight | 386.55100 |
| Exact Mass | 386.20300 |
| PSA | 69.81000 |
| LogP | 4.52580 |
| Storage condition | 2-8℃ |
| RU-SKI 43 |