N3-PEG3-CH2CH2COOH

Modify Date: 2024-01-04 22:13:24

N3-PEG3-CH2CH2COOH Structure
N3-PEG3-CH2CH2COOH structure
Common Name N3-PEG3-CH2CH2COOH
CAS Number 1056024-94-2 Molecular Weight 247.248
Density N/A Boiling Point N/A
Molecular Formula C9H17N3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N3-PEG3-CH2CH2COOH


N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

 Names

Name 3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid
Synonym More Synonyms

 N3-PEG3-CH2CH2COOH Biological Activity

Description N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related Catalog
Target

PEGs

Non-cleavable

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References

[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.

 Chemical & Physical Properties

Molecular Formula C9H17N3O5
Molecular Weight 247.248
Exact Mass 247.116821
LogP -0.71

 Synonyms

Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-
3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid
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