252881-73-5

252881-73-5 structure

Name: N3-PEG3-CH2CH2-Boc
Chemical Name: N3(CH2CH2O)3CH2CH2COOt-Bu
CAS Number: 252881-73-5
Molecular Formula: C₁₃H₂₅N₃O₅
Molecular Weight: 303.35500
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2017-03-08 09:44:47
Modify Date: 2024-01-31 10:22:16
N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	N3(CH2CH2O)3CH2CH2COOt-Bu
Synonyms	tert-butyl 12-azido-4,7,10-trioxadodecanoate tert-butyl 12-azido-4,7,10-trioxadocecanoate 12-azido-4,7,10-trioxadodecanoic acid tert-butyl ester 3-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester N3-PEG3-CH2CH2COOtBu

Description	N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Yongxin Robert ZHAO, et al. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers. WO2018086139A1. [2]. Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10(5):767-772.

Hazard Codes	Xi

Precursor 0
DownStream 1
252881-74-6